Heparin modulates the cellular uptake of nanomedicines
نویسندگان
چکیده
The presence of heparin in a biological environment affects the cellular uptake extent positively charged liposomes but not negatively liposomes.
منابع مشابه
Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
BACKGROUND Increasing use of silver nanoparticles (Ag-NPs) in various products is resulting in a greater likelihood of human exposure to these materials. Nevertheless, little is still known about the influence of carbohydrates on the toxicity and cellular uptake of nanoparticles. METHODS Ag-NPs functionalized with three different monosaccharides and ethylene glycol were synthesized and charac...
متن کاملPCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo
To elucidate how the proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor alirocumab modulates lipoprotein(a) [Lp(a)] plasma levels, the authors performed a series of Lp(a) uptake studies in primary human hepatocytes and dermal fibroblasts and measured Lp(a) secretion from human hepatocytes. They found that Lp(a) cellular uptake occurred in a low-density lipoprotein receptor-independ...
متن کاملZnO nanofluids for the improved cytotoxicity and cellular uptake of doxorubicin
Objective(s): Combination anticancer therapy holds promise for improving the therapeutic efficacy of chemotherapy drugs such as doxorubicin (DOX) as well as decreasing their dose-limiting side effects. Overcoming the side effects of doxorubicin (DOX) is a major challenge to the effective treatment of cancer. Zinc oxide nanoparticles (ZnO NPs) are emerging as potent tools for a wide variety of b...
متن کاملNanolipoparticles-mediated MDR1 siRNA delivery: preparation, characterization and cellular uptake
Objective(s): Lipid-based nanoparticles (NLP) are PEGylated carriers composed of lipids and encapsulated nucleic acids with a diameter less than 100 nm. The presence of PEG in the NLP formulation improves the particle pharmacokinetic behavior. The purpose of this study was to prepare and characterize NLPs containing MDR1 siRNA and evaluate their cytotoxicity and cellular uptake. MDR1 siRNA coul...
متن کاملThe Assessment of Toxicity Characteristics of Cellular Uptake of Paramagnetic Nanoparticles as a New Magnetic Resonance Imaging Contrast Agent
Nanoparticles are unique that enable many promising medical and technological applications intheir physical, and chemical properties. It is widely accepted that nanoparticles should bethoroughly tested for health nanotoxicity, but a moderate risk analysis is currently prevented by arevealing absence of mechanistic knowledge of nanoparticle toxicity. The purpose of this study<b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomaterials Science
سال: 2021
ISSN: ['2047-4849', '2047-4830']
DOI: https://doi.org/10.1039/d0bm01946a